Epicillin: Experimental Chemotherapy, Pharmacodynamics, and Susceptibility Testing

Epicillin: experimental chemotherapy, pharmacodynamics, and susceptibility testing.

Epicillin exhibits excellent therapeutic activity when administered orally or subcutaneously to mice infected with a variety of pathogenic bacteria. These included single strains of Streptococcus pyogenes, non-penicillinase-producing Staphylococcus aureus, Proteus mirabilis, Escherichia coli, Salmonella schottmuelleri, and Pseudomonas aeruginosa, strains of microorganisms selected as typical of...

Letter: Epicillin in gonorrhoea.

Experimental Chemotherapy

the heart of all pharmacological inquiry and the hope of chemotherapy. According to Lasagna, although drug effects are generally viewed as an inevitable sequence of phenomena induced by a stimulus, i.e., by an active chemical, pharmacological variables such as route and dose are insufficiently specified and the problems of the personality, attitudes of subjects and experimenters, or the charact...

Epicillin: in vitro laboratory studies.

A new semisynthetic penicillin, structurally related to ampicillin, has been assigned the generic name epicillin, 6-[d-2-amino-2-(1, 4-cyclohexadienyl) acetamido]-penicillanic acid. The antimicrobial spectrum and level of activity of epicillin in vitro are similar to those of ampicillin. In studies with recent clinical isolates, these two antibiotics, when compared with carbenicillin, showed co...

Molecular Identification and Conventional Susceptibility Testing of Iranian Clinical Mycobacterium fortuitum Isolates

Objective(s) Rapidly growing mycobacteria (RGM) are capable of producing diseases in humans. Since mycobacteria vary in their susceptibility, precise identification is critical for adoption of correct drug therapy. The main aim of this study was molecular identification and evaluation of antimicrobial susceptibility pattern of Iranian clinically isolated Myocbacterium fortuitum. Materials and...